Use the rocket launcher you’ve taken to the mission to eliminate tanks and APCs.

Otherwise, Big Boss might be hit (especially by tanks) and be close to dying.

It’s a good idea to order her to cover you with her sniper rifle.

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Note - The screenshot shows Quiet’s health bar (marked red above).

You don’t have to worry about it during most of the mission.

Just take care of the vehicles so they don’t stick around for too long.

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Start worrying about Quiet’s health near the end of the mission.

Refilling the supplies plays a major part in this mission.

Don’t wait for Quiet to order a supply drop, because she often does it too late.

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Designate the palace for drops so you don’t have to enter any open space.

you could place mines on both main roads leading to the palace.

In the final phase, a chopper will appear, coming towards the palace.

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You must react to it as quickly as possible, because it poses the most threat.

If you have a launcher with homing missiles, attack the chopper as soon as possible.

If not, wait until it gets closer and hovers.

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At the very end, the enemies will commence the last attack.

It means that you have to act more aggressively, because the vehicles will approach the palace faster.

A cutscene will end the battle.

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Metal Gear Solid V: The Phantom Pain